Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Phone: +81-3-5841-1418, Fax: +81-3-5841-1419
E-mail: itaka-ort@umin.net
Date of Birth: Dec 29, 1966
Nationality: Japanese
Biography:
1991 Graduation from the Faculty of Medicine, the University of Tokyo, M.D.
1991-1996 Attending orthopaedic surgeon at the Haibara General Hospital, the Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, and the Mitsui Memorial Hospital
1997-1998 Assistant Professor of the Department of Orthopaedic Surgery, The University of Tokyo Hospital
1999-2003 Graduate school of medicine, University of Tokyo
2003 Ph. D. (Medicine)
2003-2004 Researcher of the Department of Materials Science and Engineering, Graduate School of Engineering, the University of Tokyo
2004- Research Associate Professor of Nano-Bioengineering Education Program

Awards:
1. 28th International Symposium on Controlled Release of Bioactive Materials. CRS-Capsugel graduate/posdoc award (2001)
2. 28th International Symposium on Controlled Release of Bioactive Materials. The Nagai Foundation Tokyo CRS Graduate Student/Posdoc Award (2001)
3. The most outstanding presentation award in 2nd annual meeting of the society for gene and gene delivery systems. (2002)
4. The outstanding paper award of the Department of orthopaedic Surgery, the University of Tokyo (2004)

Membership:
The American Society of Gene Therapy
Controlled Release Society
The Japanese Society of Gene Design and Delivery (committee member)
The Japanese Orthopaedic Association
The Japanese Society for Biomaterials

Publications:
1. Takae S, Miyata K, Oba M, Ishii T, Itaka K, Nishiyama N, Yamasaki Y, Koyama H, Kataoka k. PEG-Detachable Polyplex Micelles Based on Disulfide-Linked Block Catiomers as Bioresponsive Non-Viral Gene Vectors. J Am Chem Soc 2008 (in press)
2. Masago K, Itaka K (double first author), Nishiyama N, Chung UI, Kataoka K. Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity. Biomaterials. 28(34):5169-75, 2007
3. Itaka K, Ohba S, Miyata K, Kawaguchi H, Nakamura K, Takato T, Chung UI, Kataoka K; Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther. 15(9):1655-62, 2007
4. Oishi M, Nagasaki Y, Nishiyama N, Itaka K, Takagi M, Shimamoto A, Furuichi Y, Kataoka K. Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)-siRNA Conjugate Formulated in PEGylated Polyplexes. ChemMedChem. 2(9):1290-1297, 2007
5. Oishi M, Hayashi H, Itaka K, Kataoka K, Nagasaki Y: pH-Responsive PEGylated nanogels as targetable and low invasive endosomolytic agents to induce the enhanced transfection efficiency of nonviral gene vectors. Colloid Polym Sci 285:1055–1060, 2007
6. Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI. Identification and characterization of the human SOX6 promoter. Biochem Biophys Res Commun. 357(2):383-90, 2007
7. Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun. 15;357(4):854-60, 2007
8. Ueno S, Ando J, Fujita H, Sugawara T, Jimbo Y, Itaka K, Kataoka K, Ushida T: The State of the Art of Nanobioscience in Japan. IEEE Trans. NanoBiosci. 5 (1), 54-65, 2006
9. Kanayama N, Fukushima S, Nishiyama N, Itaka K, Jang WD, Miyata K, Yamasaki Y, Chung UI, Kataoka K: A PEG-Based Biocompatible Block Catiomer with High Buffering Capacity for the Construction of Polyplex Micelles Showing Efficient Gene Transfer toward Primary Cells. ChemMedChem 2006; 1(4):439-44
10. Nishiyama N, Iriyama A, Jang WD, Miyata K, Itaka K, Inoue Y, Takahashi H, Yanagi Y, Tamaki Y, Koyama H, Kataoka K: Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat Mater. 4(12): 934-41, 2005
11. Wakebayashi D, Nishiyama N, Itaka K, Miyata K, Yamasaki Y, Harada A, Koyama H, Nagasaki Y, Kataoka K; Polyion Complex Micelles of pDNA withAcetal-Poly(Ethylene Glycol)-Poly (2-(Dimethylamino) Ethyl Methacrylate) Block Copolymer as Gene Carrier Systems: Physicochemical properties of Micelles Relevant to Gene Transfection Efficacy. Biomacromolecules 5:2128-2136, 2004
12. Itaka K, Kanayama N, Nishiyama N, Jang WD, Yamasaki Y, Nakamura K, Kawaguchi H, Kataoka K: Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying
diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. J Am Chem Soc 126:13612-13613, 2004
13. Oishi M, Nagasaki Y, Itaka K, Nishiyama N, Kataoka K: Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile ss-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J Am Chem Soc 127: 1624-1625, 2004
14. Itaka K, Harada A, Yamasaki Y, Nakamura K, Kawaguchi H, Kataoka K: In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. J Gene Med 6: 76-84, 2004
15. Wakebayashi D, Nishiyama N, Yamasaki Y, Itaka K, Kanayama N, Harada A, Nagasaki Y, Kataoka K: Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. J Control Release 95: 653-64, 2004
16. Itaka K, Miyata K, Harada A, Nakamura K, Kawaguchi H, and Kataoka K: Clinically Available Endosomolytic Agent for Gene Delivery. ACS Symposium series 879: 154-160, 2004
17. Ogasawara T, Kawaguchi H, Jinno S, Hoshi K, Itaka K, Takato T, Nakamura K, and Okayama H: Bone morphogenetic protein-2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. Mol Cell Biol 24(15): 6560-8, 2004
18. Yamada T, Kawano H, Sekine K, Matsumoto T, Fukuda T, Azuma Y, Itaka K, Chung U, Chambon P, Nakamura K, Kato S, and Kawaguchi H: SRC-1 is necessary for skeletal responses to sex hormones in both males and females. J Bone Miner Res. 19(9): 1452-61, 2004
19. Itaka K, Harada A, Nakamura K. Kawaguchi H. Kataoka: Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. Biomacromolecules 3: 841-5, 2002
20. Itaka K, Yamauchi K, Harada A, Nakamura K, Kawaguchi H, Kataoka K: Polyion complex micelles from plasmid DNA and poly(ethyleneglycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials 24: 4495-4506, 2003
21. Yamamoto S, Nagano A, Mikami Y, Tajiri Y, Kawano K, Itaka K: Fascicular constriction in the anterior interosseous nerve and other motor branches of the media nerve. Muscle Nerve 22: 547-548, 1999