Margareta Hammarlund-Udenaes, Ph.D., Professor, Uppsala University, Sweden
mhu@farmbio.uu.se

Dr Hammarlund-Udenaes is Professor of Pharmacokinetics and Pharmacodynamics since 1999. She received her Ph.D. in Pharmaceutical Sciences in 1984 from Uppsala University. She was a visiting scientist at University of Address:
Division of Pharmacokinetics and Drug Therapy
Department of Pharmaceutical Biosciences
Uppsala University
Box 591
751 24 Uppsala, Sweden
mhu@farmbio.uu.se

Dr Hammarlund-Udenaes is Professor of Pharmacokinetics and Pharmacodynamics since 1999. She received her Ph.D. in Pharmaceutical Sciences in 1984 from Uppsala University. She was a visiting scientist at University of California, San Francisco 1985-87 with Professor Leslie Z. Benet and 1996-97 with the late Professor Lewis B. Sheiner, and at Tohoku University, Sendai, Japan in 2004 with Professor Tetsuya Terasaki.

Dr. Hammarlund-Udenaes has supervised 10 PhD’s and co-authored around 70 original articles. She became an AAPS Fellow in 2005. She is a Field Editor of Pharmaceutical Research, and a member of the Editorial Advisory Board of the Journal of Pharmaceutical Sciences.

Her research is focused on the pharmacokinetics of blood-brain barrier transport of drugs in relation to central effects and side-effects. The influence of drug transport processes on drug delivery to the brain is theoretically investigated, as well as experimentally studied with microdialysis and PET. In vitro methods for brain drug delivery are developed based on in vivo concepts.

Recent relevant publications
(1-4)
1. Syvanen S, Hooker A, Rahman O, Wilking H, Blomquist G, Langstrom B, et al. Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier. J Pharm Sci. 2008 Apr 2.
2. Bostrom E, Hammarlund-Udenaes M, Simonsson US. Blood-brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine. Anesthesiology. 2008 Mar;108(3):495-505.
3. Hammarlund-Udenaes M, Friden M, Syvanen S, Gupta A. On The Rate and Extent of Drug Delivery to the Brain. Pharm Res. 2007 Dec 5.
4. Friden M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M. In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids. Drug Metab Dispos. 2007 Sep;35(9):1711-9.

San Francisco 1985-87 with Professor Leslie Z. Benet and 1996-97 with the late Professor Lewis B. Sheiner, and at Tohoku University, Sendai, Japan in 2004 with Professor Tetsuya Terasaki.

Her research is focused on the pharmacokinetics of blood-brain barrier transport of drugs in relation to central effects and side-effects. The influence of drug transport processes on drug delivery to the brain is theoretically investigated, as well as experimentally studied with microdialysis and PET. In vitro methods for brain drug delivery are developed based on in vivo concepts.